The definition of pure dead space is ventilation without perfusion, whereby alveolar gases do not contact blood flowing through the pulmonary capillaries.
2 Physiologic dead-space fraction (dead space divided by tidal volume ), as defined by Bohr and Enghoff, is the sum of anatomic or airway dead space (V D-anat) and alveolar dead space (V D-alv) divided by the V T. Dead-space ventilation, the portion of a tidal volume that does not contribute to gas exchange, was first described and calculated by the Bohr equation in 1891, 1 and later by the Enghoff modification of the Bohr equation in 1938.
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